Anti-CSK antibody
Specifications
| Product Cat#: | AB-06-1178 |
| Product type: | Primary antibody |
| Antigen: | CSK |
| Immunogen: | Purified recombinant fragment of human CSK expressed in E. Coli |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:1000); Immunocytochemistry (1:100-1:500); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Clonality (clone number): | Monoclonal (F1-F3) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C SRC antibody |
| C SRC kinase antibody | |
| C src Tyrosine Kinase antibody | |
| C-SRC kinase antibody | |
| C-src tyrosine kinase antibody | |
| Csk A antibody | |
| CSK antibody | |
| CSK_HUMAN antibody | |
| CYTOPLASMIC TYROSINE KINASE antibody | |
| EC 2.7.10.2 antibody | |
| MGC112926 antibody | |
| MGC117393 antibody | |
| MGC154049 antibody | |
| P60 Src antibody | |
| Protein tyrosine kinase CYL antibody | |
| Protein-tyrosine kinase CYL antibody | |
| Proto oncogene tyrosine protein kinase antibody | |
| Tyrosine protein kinase CSK antibody | |
| Tyrosine-protein kinase CSK antibody | |
| Zgc:154049 antibody |
Target information
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Provider
Erpantech Laboratory