Anti-Osteoprotegerin antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Osteoprotegerin |
| Immunogen: | Recombinant protein within human Osteoprotegerin aa 1-410 |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human,Mouse,Rat |
| Clonality (clone number): | Monoclonal (9C2) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 50% glycerol, 0.05% NaN3. |
| Concentration: | 2mg/ml |
| Purity: | Protein G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | MGC29565 antibody |
| OCIF antibody | |
| OPG antibody | |
| Osteoclastogenesis inhibitory factor antibody | |
| Osteoprotegerin antibody | |
| PDB5 antibody | |
| TNF receptor superfamily member 11b antibody | |
| TNFRSF 11B antibody | |
| TNFRSF11B antibody | |
| TR 1 antibody | |
| TR1 antibody | |
| TR11B_HUMAN antibody | |
| Tumor necrosis factor receptor superfamily member 11B antibody |
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Target information
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Provider
Erpantech Laboratory
