Anti-ZNF144 antibody
Specifications
| Product Cat#: | AB-06-4708 |
| Product type: | Primary antibody |
| Antigen: | ZNF144 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Mel18/ZNF144 145-245 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10mM Tris-HCl buffer (pH7.4), 1% BSA, 50% glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DNA binding protein Mel 18 |
| DNA-binding protein Mel-18 | |
| Mel 18 | |
| MEL-18 | |
| MGC10545 | |
| PCGF 2 | |
| PCGF2 | |
| PCGF2_HUMAN | |
| Polycomb group ring finger 2 | |
| Polycomb group RING finger protein 2 | |
| Ring finger protein 110 | |
| RNF 110 | |
| RNF110 | |
| Zinc finger protein 144 | |
| ZNF 144 |
Target information
Transcriptional repressor. Binds specifically to the DNA sequence 5′-GACTNGACT-3′. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Provider
Erpantech Laboratory