Anti-Zic2 antibody
Specifications
| Product Cat#: | AB-06-4704 |
| Product type: | Primary antibody |
| Antigen: | Zic2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Zic2 201-300/532 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Chicken, Pig, Cow, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10mM Tris-HCl buffer (pH7.4), 1% BSA, 50% glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | HPE 5 |
| HPE5 | |
| Odd paired homolog Drosophila | |
| Zic 2 | |
| Zic family member 2 (odd paired Drosophila homolog) | |
| Zic family member 2 | |
| ZIC2 | |
| ZIC2_HUMAN | |
| Zinc finger protein of the cerebellum 2 | |
| Zinc finger protein ZIC 2 |
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Target information
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5′-TGGGTGGTC-3′. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Provider
Erpantech Laboratory
