Anti-CD11b/ITAM antibody
Specifications
| Product Cat#: | AB-06-0838 |
| Product type: | Primary antibody |
| Antigen: | CD11b/ITAM |
| Immunogen: | Peptide |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Immunoprecipitation ( 1-3 μg per 100-500 μg of total protein(1 ml of cell lysate) ); Immunofluorescence; Flow Cytometry ( 1 -3μg per 1 x 106 cells ) |
| Reactivity: | Mouse and Human |
| Clonality (clone number): | Monoclonal ( 4G2 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Antigen CD11b ( p170 ) Antibody |
| Antigen CD11b p170 Antibody | |
| CD11 Antigen Like Family member B Antibody | |
| CD11 Antigen-like Family Member B Antibody | |
| CD11b Antibody |
Target information
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Provider
Erpantech Laboratory