Anti-Tyrosine Hydroxylase antibody
Specifications
| Product Cat#: | AB-06-4507 |
| Product type: | Primary antibody |
| Antigen: | Tyrosine Hydroxylase |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:50000-1:100000); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:80-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SD080-02) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Dystonia 14 antibody |
| DYT14 antibody | |
| DYT5b antibody | |
| EC 1.14.16.2 antibody | |
| OTTHUMP00000011225 antibody | |
| OTTHUMP00000011226 antibody | |
| Ple antibody | |
| Protein Pale antibody | |
| TH antibody | |
| The antibody | |
| TY3H_HUMAN antibody | |
| TYH antibody | |
| Tyrosine 3 hydroxylase antibody | |
| Tyrosine 3 monooxygenase antibody | |
| Tyrosine 3-hydroxylase antibody | |
| Tyrosine 3-monooxygenase antibody | |
| Tyrosine hydroxylase antibody |
Target information
The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.
Provider
Erpantech Laboratory
