Anti-TXNIP antibody
Specifications
| Product Cat#: | AB-06-4499 |
| Product type: | Primary antibody |
| Antigen: | TXNIP |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:5000); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:40-1:200); Immunofluorescence (1:40-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JM60-35) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | EST01027 antibody |
| HHCPA78 antibody | |
| THIF antibody | |
| Thioredoxin binding protein 2 antibody | |
| Thioredoxin interacting protein antibody | |
| Thioredoxin-binding protein 2 antibody | |
| Thioredoxin-interacting protein antibody | |
| TXNIP antibody | |
| TXNIP_HUMAN antibody | |
| Upregulated by 1,25 dihydroxyvitamin D 3 antibody | |
| VDUP1 antibody | |
| Vitamin D3 up-regulated protein 1 antibody |
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Target information
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Provider
Erpantech Laboratory
