Anti-HRG Beta 1 antibody
Specifications
| Product Cat#: | AB-06-2250 |
| Product type: | Primary antibody |
| Antigen: | HRG beta 1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Neuregulin 1 65-150/640 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:2000); Immunofluorescence(1:300-1:800); Immunohistochemistry-Paraffin (1:500-1:800); Immunocytochemistry (1:100-1:600) |
| Reactivity: | Human, Mouse, Rat, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Neuregulin 1 |
| GGF2 | |
| Acetylcholine receptor inducing activity | |
| ARIA | |
| Breast cancer cell differentiation factor p45 | |
| GGF | |
| glial growth factor | |
| Heregulin | |
| Heregulin beta1 | |
| heregulin, alpha (45kD, ERBB2 p185 activator) | |
| HGL | |
| HRG | |
| HRG beta 1A | |
| HRG1 | |
| HRGA | |
| NDF | |
| neu differentiation factor | |
| NRG1 | |
| sensory and motor neuron derived factor | |
| SMDF |
Target information
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).
Provider
Erpantech Laboratory
