Anti-Transferrin Receptor (CD71) Recombinant Rabbit Monoclonal antibody
Specifications
| Product Cat#: | AB-06-4433 |
| Product type: | Primary antibody |
| Antigen: | Transferrin Receptor (CD71) |
| Immunogen: | A synthetic peptide derived from human CD71. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JF0956) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CD 71 antibody |
| CD71 antibody | |
| CD71 antigen antibody | |
| IMD46 antibody | |
| OTTHUMP00000208523 antibody | |
| OTTHUMP00000208524 antibody | |
| OTTHUMP00000208525 antibody | |
| p90 antibody | |
| STfR antibody | |
| T9 antibody | |
| TFR 1 antibody | |
| TfR antibody | |
| TfR1 antibody | |
| TFR1_HUMAN antibody | |
| TFRC antibody | |
| TR antibody | |
| Transferrin receptor (p90 CD71) antibody | |
| Transferrin receptor protein 1, serum form antibody | |
| Trfr antibody |
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Target information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake.
Provider
Erpantech Laboratory