Anti-villin1 Recombinant Rabbit Monoclonal antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Villin1 |
| Immunogen: | Synthetic peptide within Human villin1 aa 176-225/827. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:450-1:2000); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:450-1:2000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JU34-75) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.05% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Calcium binding protein intestinal related antibody |
| Endoplasmic reticulum resident protein 70 antibody | |
| Endoplasmic reticulum resident protein 72 antibody | |
| EPR70 antibody | |
| EPR72 antibody | |
| ER protein 70 antibody | |
| ER protein 72 antibody | |
| ERP 70 antibody | |
| ERp 72 antibody | |
| ERp-72 antibody | |
| ERp70 antibody | |
| ERp72 antibody | |
| PDIA 4 antibody | |
| Pdia4 antibody | |
| PDIA4_HUMAN antibody | |
| PDIR antibody | |
| Protein disulfide isomerase A4 antibody | |
| Protein disulfide isomerase associated 4 antibody | |
| Protein disulfide isomerase family A member 4 antibody | |
| protein disulfide isomerase related protein (calcium-binding protein, intestinal-related) antibody | |
| Protein disulfide isomerase related protein antibody | |
| Protein disulfide-isomerase A4 antibody | |
| Protein ERp 72 antibody |
Target information
Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.
Provider
Erpantech Laboratory
