Anti-RPE65 antibody
Specifications
| Product Cat#: | AB-06-3919 |
| Product type: | Primary antibody |
| Antigen: | RPE65 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Immunoprecipitation (1:10-1:50) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JM61-51) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | All-trans-retinyl-palmitate hydrolase antibody |
| LCA 2 antibody | |
| LCA2 antibody | |
| Leber congenital amaurosis antibody | |
| MRPE 65 antibody | |
| MRPE65 antibody | |
| P63 antibody | |
| Rd 12 antibody | |
| Rd12 antibody | |
| Retinal pigment epithelium specific 61 kDa protein antibody | |
| Retinal pigment epithelium specific 65 kDa protein antibody | |
| Retinal pigment epithelium specific protein antibody | |
| Retinal pigment epithelium specific protein 65kDa antibody | |
| Retinal pigment epithelium-specific 65 kDa protein antibody | |
| Retinitis pigmentosa 20 antibody | |
| Retinoid isomerohydrolase antibody | |
| Retinol isomerase antibody | |
| RP 20 antibody | |
| RP20 antibody | |
| RPE 65 antibody | |
| RPE65 antibody | |
| RPE65_HUMAN antibody | |
| SRPE 65 antibody | |
| SRPE65 antibody |
Target information
Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).
Provider
Erpantech Laboratory