Anti-RNF128 antibody
Specifications
| Product Cat#: | AB-06-3890 |
| Product type: | Primary antibody |
| Antigen: | RNF128 |
| Immunogen: | KLH conjugated synthetic peptide derived from human RNF128 151-260/428 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800); Immunofluorescence (1:50-1:100); Immunocytochemistry |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Zebrafish |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | E3 ubiquitin protein ligase RNF128 |
| E3 ubiquitin-protein ligase RNF128 | |
| FLJ23516 | |
| Gene related to anergy in lymphocytes protein | |
| GRAIL | |
| Ring finger protein 128 | |
| RN128_HUMAN |
Target information
E3 ubiquitin-protein ligase that catalyzes ‘Lys-48’- and ‘Lys-63’-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with ‘Lys-48’ linkages and COR1A with ‘Lys-63’ linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
Provider
Erpantech Laboratory