Anti-RNF20 antibody
Specifications
| Product Cat#: | AB-06-3893 |
| Product type: | Primary antibody |
| Antigen: | RNF20 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000); Flow Cytometry (1:50-1:100); Immunocytochemistry (1:50-1:200); Immunoprecipitation |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (SP00-47) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | BRE1 A antibody |
| BRE1 antibody | |
| BRE1 E3 ubiquitin ligase homolog antibody | |
| BRE1-A antibody | |
| BRE1A antibody | |
| BRE1A_HUMAN antibody | |
| E3 ubiquitin-protein ligase BRE1A antibody | |
| hBRE1 antibody | |
| Homolog of S. cerevisiae BRE1 antibody | |
| RING finger protein 20 antibody | |
| Ring finger protein 20 E3 ubiquitin protein ligase antibody | |
| Rnf20 antibody |
Target information
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ‘Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ‘Lys-4’ and ‘Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
Provider
Erpantech Laboratory