Anti-RING Finger Protein 189 antibody
Specifications
| Product Cat#: | AB-06-3878 |
| Product type: | Primary antibody |
| Antigen: | RING finger protein 189 |
| Immunogen: | KLH conjugated synthetic peptide derived from human RING finger protein 189 251-363/363 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | CARP-2 |
| CARP2 | |
| Caspase regulator CARP2 | |
| Caspases 8 and 10 associated RING finger protein 2 | |
| Caspases-8 and -10-associated RING finger protein 2 | |
| E3 ubiquitin protein ligase rififylin | |
| E3 ubiquitin-protein ligase rififylin | |
| Fring | |
| FYVE RING finger protein Sakura | |
| FYVE-RING finger protein Sakura | |
| Rffl | |
| RFFL_HUMAN | |
| Rififylin | |
| RING finger and FYVE like domain containing protein | |
| RING finger and FYVE-like domain-containing protein 1 | |
| RING finger protein 189 | |
| RING finger protein 34 like | |
| RING finger protein 34-like | |
| RNF189 |
Target information
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates ‘Lys-48’-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
Provider
Erpantech Laboratory
