Anti-Integrin Alpha 4 Antibody
Specifications
| Product Cat#: | AB-06-2468 |
| Product type: | Primary antibody |
| Antigen: | Integrin alpha 4 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry (1:80-1:200); Flow Cytometry (1:20-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal(JA09-36) |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 269C wild type antibody |
| Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody | |
| CD49 antigen like family member D antibody | |
| CD49 antigen-like family member D antibody | |
| CD49d antibody | |
| IA4 antibody | |
| Integrin alpha 4 antibody | |
| Integrin alpha 4 subunit antibody | |
| Integrin alpha IV antibody | |
| Integrin alpha-4 antibody | |
| Integrin alpha-IV antibody | |
| Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody | |
| ITA4_HUMAN antibody | |
| ITGA4 antibody | |
| MGC90518 antibody | |
| OTTHUMP00000205320 antibody | |
| Very late activation protein 4 receptor, alpha 4 subunit antibody | |
| VLA 4 subunit alpha antibody | |
| VLA-4 subunit alpha antibody | |
| VLA4 antibody |
Target information
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
Provider
Erpantech Laboratory