Anti-Tim3 antibody
Specifications
| Product Cat#: | AB-06-4358 |
| Product type: | Primary antibody |
| Antigen: | Tim3 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Immunocytochemistry (1:40-1:200); Immunohistochemistry (1:80-1:200); Flow Cytometry (1:40-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (1E5) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 50% glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CD366 antibody |
| FLJ14428 antibody | |
| HAVcr-2 antibody | |
| Havcr2 antibody | |
| HAVR2_HUMAN antibody | |
| Hepatitis A virus cellular receptor 2 antibody | |
| Kidney injury molecule 3 antibody | |
| KIM 3 antibody | |
| KIM3 antibody | |
| T cell immunoglobulin and mucin domain containing 3 antibody | |
| T cell immunoglobulin mucin 3 antibody | |
| T-cell immunoglobulin and mucin domain-containing protein 3 antibody | |
| T-cell immunoglobulin mucin family member 3 antibody | |
| T-cell immunoglobulin mucin receptor 3 antibody | |
| T-cell membrane protein 3 antibody | |
| Tim 3 antibody | |
| TIM-3 antibody | |
| TIM3 antibody | |
| TIMD-3 antibody | |
| TIMD3 antibody |
Target information
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse. In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses.
Provider
Erpantech Laboratory
