Anti-ERCC8 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | ERCC8 |
| Immunogen: | KLH conjugated synthetic peptide derived from human ERCC8/CSA 161-260/396 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:1000); Immunohistochemistry-Paraffin (1:250-800) |
| Reactivity: | Human, Mouse, Rat, Horse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CKN1 |
| Cockayne syndrome type A | |
| Cockayne syndrome WD repeat protein CSA | |
| CSA | |
| DNA excision repair protein ERCC-8 | |
| DNA excision repair protein ERCC8 | |
| ERCC 8 | |
| ERCC8 | |
| ERCC8_HUMAN |
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Target information
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
Provider
Erpantech Laboratory
