Anti-Frizzled 8 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Frizzled 8 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry (1:40-1:100) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (JB40-16) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Frizzled 8 seven transmembrane spanning receptor antibody |
| Frizzled 8, seven transmembrane spanning receptor antibody | |
| Frizzled family receptor 8 antibody | |
| Frizzled homolog 8 (Drosophila) antibody | |
| Frizzled homolog 8 antibody | |
| Frizzled-8 antibody | |
| FZ 8 antibody | |
| Fz-8 antibody | |
| FZ8 antibody | |
| FZD 8 antibody | |
| FZD8 antibody | |
| FZD8_HUMAN antibody | |
| HFZ 8 antibody | |
| HFz8 antibody | |
| HGNC4046 antibody | |
| Homolog of Drosophila Frizzled 8 antibody |
Target information
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Provider
Erpantech Laboratory