Anti-Frizzled 7 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Frizzled 7 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Frizzled 7 501-574/574 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Flow Cytometry (3.5ug/Test) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Guinea Pig |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 50% glycerol, 0.03% Proclin |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Frizzled drosophila homolog of 7 |
| Frizzled homolog 7 | |
| Frizzled7 | |
| Fz 7 | |
| Fz7 | |
| FZD 7 | |
| FZD7 | |
| FzE 3 | |
| FZE3 | |
| Frizzled 3 | |
| Frizzled3 | |
| Frizzled-3 | |
| HFz 7 | |
| HFz7 |
Target information
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Provider
Erpantech Laboratory