Anti-ALDH2 Mouse Monoclonal antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | ALDH2 |
| Immunogen: | Synthetic peptide within Human ALDH2 aa 468-517/517. |
| Molecular weight: | Predicted band size: 56 kDa, Observed band size: 50 kDa |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:1000-1:5000); Immunohistochemistry (1:50-1:200); Immunocytochemistry/Immunofluorescence (1:50-1:200); Flow Cytometry (1:25-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, E4-D10 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.2% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Acetaldehyde dehydrogenase 2 antibody |
| Aldehyde dehydrogenase 2 family (mitochondrial) antibody | |
| Aldehyde dehydrogenase 2 family antibody | |
| Aldehyde dehydrogenase mitochondrial antibody | |
| Aldehyde dehydrogenase, mitochondrial antibody |
Target information
Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1); aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase cytosolic; ALDHII; ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). The major liver isoform ALDH1 localizes to cytosolic space, while ALDH2 localizzes to the mitochondria. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH2 is present in most Caucasians, yet is absent in 50% of Asians. The absence of this enzyme has been linked to alcohol intolerance; and thusly, a reduced risk for alcoholism-related liver disease.
Provider
Erpantech Laboratory
