Anti-Moesin antibody
Specifications
| Product Cat#: | AB-06-2927 |
| Product type: | Primary antibody |
| Antigen: | Moesin |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Flow Cytometry (1:50-1:100); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SC69-01) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | Epididymis luminal protein 70 antibody |
| HEL70 antibody | |
| Membrane organizing extension spike protein antibody | |
| Membrane-organizing extension spike protein antibody | |
| MOES_HUMAN antibody | |
| Moesin antibody | |
| Moesin/anaplastic lymphoma kinase fusion protein antibody | |
| Msn antibody | |
| MSN/ALK fusion antibody |
Target information
Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (PubMed:27405666).
Provider
Erpantech Laboratory