Anti-MNK2 antibody
Specifications
| Product Cat#: | AB-06-2925 |
| Product type: | Primary antibody |
| Antigen: | MNK2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human MNK2 1-100/465 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Cow, Sheep, Guinea Pig |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | G protein coupled receptor kinase 7 |
| GPRK7 | |
| MAP kinase interacting serine threonine kinase 2 | |
| MAP kinase interacting serine threonine kinase | |
| MAP kinase interacting serine threonine protein kinase 2 | |
| MAP kinase signal integrating kinase 2 | |
| MAP kinase signal-integrating kinase 2 | |
| MAP kinase-interacting serine/threonine-protein kinase 2 | |
| MAPK interacting kinase 2 | |
| MAPK signal integrating kinase 2 | |
| Mitogen activated protein kinase interacting serine threonine kinase 2 | |
| Mknk2 | |
| MKNK2_HUMAN | |
| Mnk2 |
Target information
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O3-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Provider
Erpantech Laboratory
