Anti-MLKL antibody
Specifications
| Product Cat#: | AB-06-2902 |
| Product type: | Primary antibody |
| Antigen: | MLKL |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:5000); Immunohistochemistry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (SA40-04) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | 9130019I15Rik antibody |
| FLJ34389 antibody | |
| hMLKL antibody | |
| Mixed lineage kinase domain like antibody | |
| Mixed lineage kinase domain like protein antibody | |
| Mixed lineage kinase domain-like protein antibody | |
| Mlkl antibody | |
| MLKL_HUMAN antibody |
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Target information
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
Provider
Erpantech Laboratory