Anti-HIF-1 Alpha antibody
Specifications
| Product Cat#: | AB-06-2158 |
| Product type: | Primary antibody |
| Antigen: | HIF-1 alpha |
| Immunogen: | Peptide corresponding to residues of HIF-1 of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:800-1:1500); Immunoprecipitation ( 1-2 μg per 100-500 μg of total protein); Immunohistochemistry (1:50-1:800); Immunocytochemistry (1:100-1:800) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal （5H7） |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4),1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ARNT interacting protein antibody |
| ARNT-interacting protein antibody | |
| Basic helix loop helix PAS protein MOP1 antibody | |
| Basic-helix-loop-helix-PAS protein MOP1 antibody | |
| BHLHe78 antibody | |
| Class E basic helix-loop-helix protein 78 antibody | |
| HIF 1A antibody | |
| HIF 1alpha antibody | |
| HIF-1-alpha antibody | |
| HIF1 A antibody | |
| HIF1 Alpha antibody | |
| HIF1 antibody | |
| HIF1-alpha antibody | |
| HIF1A antibody | |
| HIF1A_HUMAN antibody | |
| Hypoxia inducible factor 1 alpha antibody | |
| Hypoxia inducible factor 1 alpha isoform I.3 antibody | |
| Hypoxia inducible factor 1 alpha subunit antibody | |
| Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor antibody | |
| Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor) antibody | |
| Hypoxia inducible factor1alpha antibody | |
| Hypoxia-inducible factor 1-alpha antibody | |
| Member of PAS protein 1 antibody | |
| Member of PAS superfamily 1 antibody | |
| Member of the PAS Superfamily 1 antibody | |
| MOP 1 antibody | |
| MOP1 antibody | |
| PAS domain-containing protein 8 antibody |
Target information
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5′-TACGTG-3′ within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Provider
Erpantech Laboratory
