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Anti-AIM2 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-0191
Anti-AIM2 antibody
Erpan Tech In stock

Specifications        

Product type: Primary antibody
Antigen: AIM2
Immunogen: Purified recombinant fragment of human AIM2 expressed in E. Coli.
Species immunized: Mouse
Isotype: IgG
Applications: Western Blot (1:200-1:2000); Immunocytochemistry (1:100-1:200); Flow Cytometry (1:100-1:200)
Reactivity: Human
Clonality (clone number): Monoclonal, 4G-11
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3.
Concentration: 1mg/ml
Purity: Protein A/G affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Absent in melanoma 2 antibody
AIM 2 antibody
Aim2 antibody
AIM2_HUMAN antibody
Interferon-inducible protein AIM2 antibody
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Target information

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Provider

Erpantech Laboratory

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