Anti-TAZ antibody
Specifications
| Product Cat#: | AB-06-4281 |
| Product type: | Primary antibody |
| Antigen: | TAZ |
| Immunogen: | KLH conjugated synthetic peptide derived from human TAZ 1-100/400 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot; Flow Cytometry (2ug/test) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Transcriptional co activator with PDZ binding motif |
| Transcriptional coactivator with PDZ binding motif | |
| Transcriptional coactivator with PDZ-binding motif | |
| WW domain containing transcription regulator 1 | |
| WW domain containing transcription regulator protein 1 | |
| WW domain-containing transcription regulator protein 1 | |
| WWTR 1 | |
| WWTR1 |
Target information
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Provider
Erpantech Laboratory
