Anti-RBPJK antibody
Specifications
| Product Cat#: | AB-06-3837 |
| Product type: | Primary antibody |
| Antigen: | RBPJK |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:5000) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JB49-34) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | AI843960 antibody |
| AOS3 antibody | |
| CBF 1 antibody | |
| CBF-1 antibody | |
| CBF1 antibody | |
| CSL antibody | |
| IGKJRB antibody | |
| IGKJRB1 antibody | |
| J kappa recombination signal binding protein antibody | |
| J kappa-recombination signal-binding protein antibody | |
| KBF2 antibody | |
| NY REN 30 antigen antibody | |
| RBP J antibody | |
| RBP J kappa antibody | |
| RBP JK antibody | |
| RBP-J antibody | |
| RBP-J kappa antibody | |
| RBP-JK antibody | |
| Rbpj antibody | |
| RBPJK antibody | |
| RBPSUH antibody | |
| Recombination signal binding protein for immunoglobulin kappa J region antibody | |
| Recombining binding protein suppressor of hairless antibody | |
| Renal carcinoma antigen NY-REN-30 antibody | |
| SUH antibody |
Target information
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).
Provider
Erpantech Laboratory