Anti-Nectin 3 antibody
Specifications
| Product Cat#: | AB-06-3074 |
| Product type: | Primary antibody |
| Antigen: | Nectin 3 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Nectin 3 431-549/549 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:400-1:2000 ) |
| Reactivity: | Human, Mouse, Rat, Cow, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS ( pH7.4 ) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CD113 |
| CDw113 | |
| DKFZP566B0846 | |
| FLJ90624 | |
| Nectin-3 | |
| Nectin3 | |
| Poliovirus Receptor Related 3 | |
| Poliovirus Receptor Related Protein 3 | |
| Poliovirus Receptor-related Protein 3 | |
| PPR3 |
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Target information
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Provider
Erpantech Laboratory
