Anti-RAD50 antibody
Specifications
| Product Cat#: | AB-06-3805 |
| Product type: | Primary antibody |
| Antigen: | RAD50 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human, Rat |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | DNA repair protein RAD50 antibody |
| hRAD50 antibody | |
| hsRAD50 antibody | |
| Mrell antibody | |
| NBSLD antibody | |
| Rad 50 antibody | |
| RAD50 2 antibody | |
| rad50 antibody | |
| RAD50 homolog (S cerevisiae) antibody | |
| RAD50 homolog antibody | |
| RAD50 PEN antibody | |
| RAD50, S. cerevisiae, homolog of antibody | |
| RAD50_HUMAN antibody | |
| RAD502 antibody | |
| Rad50l antibody | |
| Truncated RAD50 protein antibody |
Target information
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3′-5′ exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
Provider
Erpantech Laboratory
