Anti-AF10 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | AF10 |
| Immunogen: | KLH conjugated synthetic peptide derived from human AF10/MLLT10 151-250/1027 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Flow Cytometry (1ug/test) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified/Antigen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AF 10 |
| AF10_HUMAN | |
| ALL 1 fused gene from chromosome 10 | |
| ALL1-fused gene from chromosome 10 protein | |
| MLLT 10 | |
| Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog Drosophila) translocated to 10 | |
| Myeloid/lymphoid or mixed lineage leukemia translocated to 10 | |
| Protein AF 10 |
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Target information
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 ‘Lys-79’ dimethylation (H3K79me2) and gene activation (PubMed:26439302).
Provider
Erpantech Laboratory
