Anti-LXR Alpha + LXR Beta antibody
Specifications
| Product Cat#: | AB-06-2757 |
| Product type: | Primary antibody |
| Antigen: | LXR Alpha + LXR Beta |
| Immunogen: | KLH conjugated synthetic peptide derived from human LXR alpha + LXR beta 51-150/447 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Xenopus laevis |
| Clonality (clone number): | Polyclonal |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Liver X receptor alpha |
| Liver X receptor alpha | |
| Liver X receptor beta | |
| LXR a | |
| LXR | |
| LXR b | |
| LXRa | |
| LXRalpha | |
| LXRb | |
| LXRbeta | |
| NER | |
| NERI | |
| NR1H2 | |
| NR1H3 | |
| Nuclear orphan receptor LXR alpha | |
| Nuclear orphan receptor LXR beta | |
| Nuclear receptor NER | |
| Nuclear receptor subfamily 1 group H member 2 | |
| Nuclear receptor subfamily 1 group H member 3 | |
| Oxysterols receptor LXR alpha | |
| Oxysterols receptor LXR beta | |
| RIP15 | |
| RLD1 | |
| Ubiquitously expressed nuclear receptor |
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Target information
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5′-AGGTCA-3′ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
Provider
Erpantech Laboratory