Anti-IL28A antibody
Specifications
| Product Cat#: | AB-06-2414 |
| Product type: | Primary antibody |
| Antigen: | L28A |
| Immunogen: | Purified recombinant fragment of human IL28A expressed in E. Coli. |
| Species immunized: | Rabbit |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry (1:80-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (A4-B9) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cytokine ZCYTO20 antibody |
| IFN-lambda-2 antibody | |
| IFNL2 antibody | |
| IL-28A antibody | |
| IL28A antibody | |
| IL28A_HUMAN antibody | |
| Interferon lambda 2 antibody | |
| Interferon lambda-2 antibody | |
| Interleukin 28A (interferon, lambda 2) antibody | |
| Interleukin 28A antibody | |
| Interleukin-28A antibody | |
| ZCYTO20 antibody |
Target information
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Provider
Erpantech Laboratory
