Anti-IL-10 antibody
Specifications
| Product Cat#: | AB-06-2386 |
| Product type: | Primary antibody |
| Antigen: | IL-10 |
| Immunogen: | KLH conjugated synthetic peptide derived from human IL-10 101-178/178 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry-Paraffin (1:500-800) |
| Reactivity: | Mouse, Rat, Chicken, Pig, Rabbit, Sheep, Guinea Pig and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Interleukin-10 precursor |
| Cytokine synthesis inhibitory factor | |
| CSIF | |
| Cytokine Synthesis Inhibitory Factor | |
| IL 10 | |
| IL10A | |
| Interleukin 10 | |
| Interleukin10 | |
| MGC126450 | |
| MGC126451 | |
| TGIF |
Target information
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity) (PubMed:28473584).
Provider
Erpantech Laboratory
