Anti-Caspase-8 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Caspase-8 |
| Immunogen: | Full-length recombinant caspase-8 of human origin |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:200-1:1000); Immunoprecipitation (1-2 μg per 100-500 μg of total protein); Immunofluorescence (1:100-500); Immunohistochemistry-Paraffin (1:100-500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, 6G1 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ALPS2B antibody |
| Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody | |
| Apoptotic cysteine protease antibody | |
| Apoptotic protease Mch-5 antibody | |
| Apoptotic protease Mch5 antibody | |
| CAP4 antibody | |
| CASP-8 antibody | |
| CASP8 antibody | |
| CASP8_HUMAN antibody | |
| Caspase 8 antibody | |
| Caspase 8 apoptosis related cysteine peptidase antibody | |
| Caspase-8 subunit p10 antibody | |
| CED 3 antibody | |
| FADD Like ICE antibody | |
| FADD-homologous ICE/CED-3-like protease antibody | |
| FADD-like ICE antibody | |
| FLICE antibody | |
| FLJ17672 antibody | |
| ICE-like apoptotic protease 5 antibody | |
| MACH alpha 1/2/3 protein antibody | |
| MACH antibody | |
| MACH beta 1/2/3/4 protein antibody | |
| MCH5 antibody | |
| MGC78473 antibody | |
| MORT1 associated ced 3 homolog antibody | |
| MORT1-associated CED-3 homolog antibody | |
| OTTHUMP00000163717 antibody | |
| OTTHUMP00000163720 antibody | |
| OTTHUMP00000163724 antibody | |
| OTTHUMP00000163725 antibody | |
| OTTHUMP00000165062 antibody | |
| OTTHUMP00000165063 antibody | |
| OTTHUMP00000165064 antibody | |
| OTTHUMP00000206552 antibody |
Target information
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Provider
Erpantech Laboratory
