Anti-MADH7/Smad7 antibody
Specifications
| Product Cat#: | AB-06-2776 |
| Product type: | Primary antibody |
| Antigen: | MADH7/Smad7 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Smad7 1-100/426 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Pig, Cow |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | hSMAD 7 |
| HSMAD7 | |
| MAD (mothers against decapentaplegic Drosophila) homolog 7 | |
| MAD | |
| Mad homolog 7 | |
| MAD mothers against decapentaplegic homolog 7 | |
| MADH 7 | |
| MADH 8 | |
| MADH8 | |
| Mothers Against Decapentaplegic Drosophila Homolog of 7 | |
| Mothers against decapentaplegic homolog 7 | |
| Mothers against decapentaplegic homolog 8 | |
| Mothers against DPP homolog 7 | |
| Mothers against DPP homolog 8 | |
| SMA- AND MAD-RELATED PROTEIN 7 | |
| SMAD 7 | |
| SMAD | |
| SMAD family member 7 | |
| SMAD, mothers against DPP homolog 7 (Drosophila) | |
| SMAD, mothers against DPP homolog 7 | |
| Smad7 |
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Target information
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Provider
Erpantech Laboratory