Anti-Fas Ligand antibody
Specifications
| Product Cat#: | AB-06-1666 |
| Product type: | Primary antibody |
| Antigen: | Fas Ligand |
| Immunogen: | KLH conjugated synthetic peptide derived from human Fas Ligand 196-281/281 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:450-1:800); Flow Cytometry (1μg/Test);Immunofluorescence (1:100-1:450);Immunocytochemistry (1:100-1:450) |
| Reactivity: | Human, Mouse, Rat, Cow |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS(pH7.4) with 1% BSA; 0.03% Proclin 300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | APO1L |
| Apoptosis (APO 1) antigen ligand 1 | |
| Fas-L | |
| Apoptosis antigen ligand 1 | |
| APTL | |
| CD 178 | |
| CD-178 | |
| CD 178 | |
| CD95L | |
| CD95 ligand | |
| CD95-L | |
| CD95L protein | |
| FAS antigen ligand | |
| Fas L | |
| Fas Ligand | |
| FASL | |
| Fasl | |
| Fas ligand (TNF superfamily member 6) | |
| Generalized lymphoproliferative disease | |
| TNF superfamily member 6 | |
| TNFSF 6 | |
| Tumor necrosis factor ligand superfamily member 6 | |
| TNFL6_HUMAN | |
| Apoptosis antigen ligand | |
| Tumor necrosis factor ligand superfamily member 6, membrane form | |
| Tumor necrosis factor ligand superfamily member 6, soluble form |
Target information
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).
Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260).
FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition.
Provider
Erpantech Laboratory
