Anti-MacroH2A.1 antibody
Specifications
| Product Cat#: | AB-06-2770 |
| Product type: | Primary antibody |
| Antigen: | MacroH2A.1 |
| Immunogen: | Recombinant protein within human macroH2A.1 aa 200-400 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 0.5% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Core histone macro h2a.1 antibody |
| Core histone macro-H2A.1 antibody | |
| H2A histone family member Y antibody | |
| H2A.y antibody | |
| H2A/y antibody | |
| H2AF12M antibody | |
| H2AFJ antibody | |
| H2afy antibody | |
| H2AY_HUMAN antibody | |
| Histone H2A.Y antibody | |
| Histone macroH2A1 antibody | |
| Histone macroH2A1.1 antibody | |
| Histone macroH2A1.2 antibody | |
| Macroh2a1 antibody | |
| MACROH2A1.1 antibody | |
| MacroH2A1.2 antibody | |
| Medulloblastoma antigen MU MB 50.205 antibody | |
| Medulloblastoma antigen MU-MB-50.205 antibody | |
| MH2a antibody | |
| MH2A1 antibody |
Target information
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708).
Provider
Erpantech Laboratory
