Anti-KAP1 antibody
Specifications
| Product Cat#: | AB-06-2548 |
| Product type: | Primary antibody |
| Antigen: | KAP1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:2000-1:5000); Immunohistochemistry(1:50-1:200); Immunocytochemistry (1:50-1:500); Flow Cytometry (1:50-1:100); Immunofluorescence |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SD081-05) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 50% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 3 SUMO Protein Ligase TRIM28 antibody |
| E3 SUMO-Protein Ligase TRIM28 antibody | |
| FLJ29029 antibody | |
| KAP 1 antibody | |
| KAP-1 antibody | |
| KRAB Associated Protein 1 antibody | |
| KRAB Interacting Protein 1 antibody | |
| KRAB-Associated Protein 1 antibody | |
| KRAB-Interacting Protein 1 antibody | |
| KRIP 1 antibody | |
| KRIP-1 antibody | |
| KRIP1 antibody | |
| Nuclear Corepressor KAP 1 antibody | |
| Nuclear Corepressor KAP-1 antibody | |
| RING Finger Protein 96 antibody | |
| RNF96 antibody | |
| TF1B antibody | |
| TIF1 Beta antibody | |
| TIF1-Beta antibody | |
| TIF1B antibody | |
| TIF1B_HUMAN antibody | |
| Transcription Intermediary Factor 1 Beta antibody | |
| Transcription Intermediary Factor 1-Beta antibody | |
| Trim28 antibody | |
| Tripartite Motif Containing 28 antibody | |
| tripartite Motif Containing Protein 28 antibody | |
| Tripartite Motif-Containing Protein 28 antibody |
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Target information
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ‘Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ‘Lys-9 and ‘Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1.
Provider
Erpantech Laboratory