Anti-COE1 antibody
Specifications
| Product Cat#: | AB-08-0117 |
| Product type: | Primary antibody |
| Antigen: | COE1 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human EBF1. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 50% Glycerol, 0.02% NaN3. |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | EBF1; EBF Transcription Factor 1; COE1; OLF1; EBF; Transcription Factor COE1; Early B Cell Factor 1; Early B-Cell Factor; O/E-1; Collier, Olf And EBF Transcription Factor 1; Olfactory Neuronal Transcription Factor 1; OE-1 |
Target information
Key pioneer transcription factor of B-cell specification and commitment.
Recognizes variations of the palindromic sequence 5′-ATTCCCNNGGGAATT-3′. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold.
(Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells.
In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency.
Provider
Erpantech Laboratory
