Anti-mTOR (phospho ser2448) antibody
Specifications
| Product Cat#: | AB-06-4863 |
| Product type: | Primary antibody |
| Antigen: | mTOR (phospho ser2448) |
| Immunogen: | Synthetic peptide within human mTOR aa 2430-2480. |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Immunohistochemistry-Paraffin (1:40-200); Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal, A5D5 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.05% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein G affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) antibody |
| FK506 binding protein 12 rapamycin associated protein 1 antibody | |
| FK506 binding protein 12 rapamycin associated protein 2 antibody | |
| FK506 binding protein 12 rapamycin complex associated protein 1 antibody | |
| FK506-binding protein 12-rapamycin complex-associated protein 1 antibody | |
| FKBP rapamycin associated protein antibody | |
| FKBP12 rapamycin complex associated protein antibody | |
| FKBP12-rapamycin complex-associated protein 1 antibody | |
| FKBP12-rapamycin complex-associated protein antibody | |
| FLJ44809 antibody | |
| FRAP antibody | |
| FRAP1 antibody | |
| FRAP2 antibody | |
| Mammalian target of rapamycin antibody | |
| Mechanistic target of rapamycin antibody | |
| mTOR antibody | |
| MTOR_HUMAN antibody | |
| OTTHUMP00000001983 antibody | |
| RAFT1 antibody | |
| Rapamycin and FKBP12 target 1 antibody | |
| Rapamycin associated protein FRAP2 antibody | |
| Rapamycin target protein 1 antibody | |
| Rapamycin target protein antibody | |
| RAPT1 antibody | |
| Serine/threonine-protein kinase mTOR antibody |
Target information
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene.
Provider
Erpantech Laboratory
