Anti-KDM6B antibody
Specifications
| Product Cat#: | AB-08-0098 |
| Product type: | Primary antibody |
| Antigen: | KDM6B |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 265-450 of mouse Kdm6b (NP_001017426.1). |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunofluorescence (1:40-1:200) |
| Reactivity: | Human, Mouse |
| Clonality: | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.3), 50% Glycerol, 0.02% NaN3. |
| Purity: | Immoungen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | KDM6B; JMJD3; Kdm6b |
Target information
Histone demethylase that specifically demethylates ‘Lys-27’ of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914).
Demethylates trimethylated and dimethylated H3 ‘Lys-27’ (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914).
Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529).
Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402).
Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).
Provider
Erpantech Laboratory
