Anti-NAK / TBK1 antibody
Specifications
| Product Cat#: | AB-06-3041 |
| Product type: | Primary antibody |
| Antigen: | NAK / TBK1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:400-1:1500 ); Immunoprecipitation ( 1:50 ) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal ( 2G1) |
| Form: | Liquid |
| Buffer: | 1*TBS ( pH7.4 ), 1 %BSA, 40 %Glycerol. Preservative: 0.05 % Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | EC 2.7.11.1 antibody |
| FLJ11330 antibody | |
| NAK antibody | |
| NF kappa B activating kinase antibody | |
| NF kB activating kinase antibody | |
| NF-kappa-B-activating kinase antibody | |
| Serine/threonine protein kinase TBK 1 antibody | |
| Serine/threonine protein kinase TBK1 antibody | |
| Serine/threonine-protein kinase TBK1 antibody | |
| T2K antibody | |
| TANK binding kinase 1 antibody | |
| TANK-binding kinase 1 antibody | |
| TBK 1 antibody | |
| Tbk1 antibody | |
| TBK1_HUMAN antibody |
Target information
The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. TANK binding kinase (TBK1), also designated T2K, is a novel IKK-related kinase that has been identified in murine and human tissues. TBK1 was shown to complex with TRAF2 and TANK in the NFκB activation pathway. TBK1 shares homology with IKKα and IKKβ in the amino-terminal half, which includes the kinase domain.
Provider
Erpantech Laboratory
