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Anti-GC1q R antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1865
Anti-GC1q R antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1865
Product type: Primary antibody
Antigen: GC1q R
Immunogen: KLH conjugated synthetic peptide derived from human C1QBP 101-200/282
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:2000)
Reactivity: Human, Mouse, Rat, Dog, Pig, Sheep
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Alternative names: C1q globular domain binding protein
C1QBP
GC1q R
C1QBP_HUMAN antibody Complement component 1 q subcomponent binding protein
Complement component 1 Q subcomponent binding protein mitochondrial
Complement component 1 Q subcomponent-binding protein, mitochondrial
GC1Q R
GC1q R protein
GC1q-R protein
GC1QBP
GC1QR
Glycoprotein gC1qBP
HABP 1
HABP1
Hyaluronan binding protein 1
Hyaluronan-binding protein 1
Mitochondrial matrix protein p32
p32 antibody p33 antibody Pre mrna splicing factor SF2 P32 subunit
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Target information

Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular “heads” of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection.

Provider

Erpantech Laboratory

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MSDS-AB-06-1865.pdf (169 downloads )