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Anti-GBA antibody (KO Validated)

SKU Product Brand Unit Availability Price Quantity  
AB-06-1863
Anti-GBA antibody (KO Validated)
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1863
Product type: Primary antibody
Antigen: GBA
Immunogen: Synthetic peptide within Human GBA aa 477-534/536.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:1000-1:5000); Immunohistochemistry-Paraffin (1:50-1:200)
Reactivity: Human, Rat, Mouse
Clonality (clone number): Monoclonal (JM10-76)
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Alternative names: Acid beta glucosidase antibody
Acid beta-glucosidase antibody
Alglucerase antibody
Beta glucocerebrosidase antibody
BETA GLUCOSIDASE, ACID antibody
Beta-glucocerebrosidase antibody
betaGC antibody
D glucosyl N acylsphingosine glucohydrolase antibody
D-glucosyl-N-acylsphingosine glucohydrolase antibody
EC 3.2.1.45 antibody
GBA antibody
Gba protein antibody
GBA1 antibody
GC antibody
GCase antibody
GCB antibody
GLCM_HUMAN antibody
GLUC antibody
Glucocerebrosidase (alt.) antibody
Glucocerebrosidase antibody
GLUCOCEREBROSIDASE PSEUDOGENE antibody
Glucosidase beta antibody
Glucosidase, beta, acid antibody
Glucosidase, beta; acid (includes glucosylceramidase) antibody
Glucosylceramidase antibody
Imiglucerase antibody
Lysosomal glucocerebrosidase antibody
OTTHUMP00000033992 antibody
OTTHUMP00000033993 antibody
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Target information

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Also plays a role in cholesterol metabolism (PubMed:24211208, PubMed:26724485). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208, PubMed:26724485). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PubMed:26724485). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (PubMed:24211208, PubMed:26724485).

Provider

Erpantech Laboratory

download

MSDS-AB-06-1863.pdf (111 downloads )