Anti-GIMAP5 antibody
Specifications
| Product Cat#: | AB-07-0555 |
| Product type: | Primary antibody |
| Antigen: | GIMAP5 |
| Immunogen: | A synthetic peptide derived from human GIMAP5 . The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot: 1:500~1:3000 |
| Immunohistochemistry: 1:50~1:100 ELISA: 1:20000 | |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | GIMAP5 ;GIMA5; GTPase, IMAP family 5; HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3; Immunity-associated 3; Immunity-associated nucleotide 4-like 1 |
靶标信息
Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca2+ homeostasis by modulating lysosomal Ca2+ stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity).
产品来源
洱畔科技实验室
