Anti-IKK-γ (Ab-31) antibody
Specifications
| Product Cat#: | AB-07-0664 |
| Product type: | Primary antibody |
| Antigen: | IKK-γ (Ab-31) |
| Immunogen: | A synthetic peptide derived from human IKK-γ around the phosphorylation site of serine 31 (E-E-SP- P-L). The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2500); Immunohistochemistry (1:50-1:100); ELISA (1:40000) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | FIP-3; FIP3; I-kappa-B kinase gamma; IKBKG; IKK-gamma; IKKAP1; IKKG; IkB kinase gamma subunit; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase gamma subunit; NEMO; NF-kappaB essential modifier; NF-kappaB essential modulator |
Target information
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ‘Lys-63’-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires ‘Lys-27’-linked polyubiquitination.
Provider
Erpantech Laboratory
