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Anti-FLT3 (Phospho-Tyr969) antibody

SKU Product Brand Unit Availability Price Quantity  
AB-07-0516
Anti-FLT3 (Phospho-Tyr969) antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-07-0516
Product type: Primary antibody
Antigen: FLT3 (Phospho-Tyr969)
Immunogen: A synthetic peptide derived from human FLT3 (Phospho-Tyr969) . The exact amino-acid sequence is proprietary.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot: 1:500~1:3000 Immunohistochemistry: 1:50~1:100 ELISA: 1:5000
Reactivity: Human
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: FLT3 (Phospho-Tyr969);CD135; EC 2.7.10.1; fetal liver kinase 2; FL cytokine receptor; FLK-2; FLT-3; FLT3; fms-related tyrosine kinase 3; kinase Flt3; stem cell tyrosine kinase 1; STK-1; STK1
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Target information

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Provider

Erpantech Laboratory

download

MSDS-AB-07-0516.pdf (96 downloads )