Anti-CARD15/NOD2 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | CARD15/NOD2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human CARD15 251-350/1040 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ACUG |
| Arthrocutaneouveal granulomatosis | |
| BLAU | |
| CARD15 | |
| Caspase recruitment domain protein 15 | |
| Caspase recruitment domain-containing protein 15 | |
| CD | |
| IBD1 | |
| Inflammatory bowel disease protein 1 | |
| LRR containing protein | |
| LRR-containing protein | |
| Nod2 | |
| NOD2 protein | |
| NOD2_HUMAN | |
| NOD2B | |
| Nucleotide binding oligomerization domain 2 | |
| Nucleotide-binding oligomerization domain 2 | |
| Nucleotide-binding oligomerization domain-containing protein 2 |
Target information
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).
Provider
Erpantech Laboratory
