Anti-CARD14 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | CARD14 |
| Immunogen: | KLH conjugated synthetic peptide derived from human CARD14 1-100/1004 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Bcl10 interacting MAGUK protein 2 |
| Bimp 2 | |
| Bimp2 | |
| CARD 14 | |
| CARD containing MAGUK 2 protein | |
| CARD containing MAGUK protein 2 | |
| Card maguk protein 2 | |
| Carma 2 | |
| Carma2 | |
| Caspase recruitment domain containing protein 14 | |
| Caspase recruitment domain family member 14 | |
| Caspase recruitment domain protein 14 |
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Target information
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
Provider
Erpantech Laboratory
