Anti-GRAMD1A antibody
Specifications
| Product Cat#: | AB-06-2028 |
| Product type: | Primary antibody |
| Antigen: | GRAMD1A |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgM |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry-Paraffin (1:100-200) ; Immunocytochemistry (1:100-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (1-E4) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Target information
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192).
Provider
Erpantech Laboratory
